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Various of pharmaceutical strategies for oral administration including solid dispersions, nano/microparticles, polymeric micelles,. Cryo-milling · salt formation · spray drying · co-crystallization · hot-melt extrusion. Specific strategies to improve the oral bioavailability of biopharmaceuticals are also discussed. Keywords: biopharmaceuticals, formulation, macromolecules,. The prodrug design can improve the oral bioavailability of drugs by enhancing their water solubility and gastrointestinal permeability and. The current study offers an exploratory strategy to overcome poor solubility/dissolution, poor permeability, and metabolism by cytochrome p450. Increasing oral bioavailability through nanomedicine. The use of nanoparticles to enhance oral drug delivery is supported by recent evidence. This article reviews the approaches that have been successfully applied to improve oral drug bioavailability, primarily, prodrug strategies, lead optimisation. Improvement of the oral bioavailability of drugs. Briefly, the design of prodrugs to bypass metabolism or to enhance solubility as well as Hebei Runk Tech Co,, how to improve oral bioavailability.
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